Metabolic syndrome is a cluster of conditions that occur together, increasing the risk of heart disease, stroke, and type 2 diabetes. It's characterized by a combination of factors including:
These factors often occur together and exacerbate each other, creating a vicious cycle that significantly increases the risk of serious health problems, including heart attacks, strokes, and diabetes.
Metabolic syndrome is closely linked to lifestyle factors such as unhealthy diet, lack of physical activity, and obesity. Genetics also play a role in predisposing some individuals to develop metabolic syndrome.
Preventing or managing metabolic syndrome typically involves lifestyle changes such as adopting a healthy diet, increasing physical activity, losing weight (especially around the waistline), and managing stress. Early detection and intervention are crucial in reducing the risk of complications associated with metabolic syndrome.
The metabolic disorders chosen for this analysis included central obesity, diabetes, hypertension, dyslipidemia, renal failure, nonalcoholic fatty liver disease, polycystic ovary syndrome, sleep apnea, certain cancers, vascular atherosclerosis, and cardiovascular disease.
… disorders linked to the metabolic syndrome are associated with high levels of insulin, suggesting that these diseases share a common etiologythat is expressed by high levels of insulin. This leads us to propose the concept of a “hyperinsulinemic syndrome” and question the safety of insulin as a chronic therapy for patients with T2DM.
https://www.surgjournal.com/article/S0039-6060(14)00198-6/abstract
Insulin resistance in young South Asian men can be observed even without increase in IP fat mass and is related to large SA adipocytes size. Hence ethnic excess in insulin resistance in South Asians appears to be related more to excess truncal fat and dysfunctional adipose tissue than to excess visceral fat.
Insulin is essential for brain function. IR, which leads to insulin dysregulation, can cause neurological damage via a variety of mechanisms. Numerous studies have shown that IR is not just a feature of T2D, but it also plays a key role in the development and progression of ischemic stroke. IR is an independent risk factor for ischemic stroke, IR contributes to the development of ischemic stroke by promoting thrombosis and atherosclerosis formation.
While diabetes/insulin-resistance and breast cancer are distinct diseases, insulin-signaling plays a central role in both illnesses. Insulin activates key cancer processes including EMT, tissue inflammation, motility, and angiogenesis.
Higher fasting serum insulin concentrations, as well as the presence of insulin resistance, appear to be associated with an elevated risk of lung cancer development.
Brain insulin resistance is a significant feature of Alzheimer’s disease (AD). This phenomenon by itself can promote many of the neural and cognitive abnormalities of AD. In individuals with or without a history of diabetes, brain insulin resistance is an early and common feature of AD, closely associated with cognitive decline.